When the time came to dial up a big play for Michael Thomas, the Saints' leading receiver answered the call.
Tom Brady threw for 294 yards and a touchdown, and James White ran for two scores to lead the Patriots to a 31-17 victory over Aaron Rodgers and the Packers.
It's another victory for the surging LA Chargers, holding off Russell Wilson's late rally for a 25-17 win over the Seattle Seahawks.
A resilient defense helped the Miami Dolphins beat the hapless New York Jets 13-6.
Patrick Mahomes is making this look way too easy.
The Carolina Panthers built an early lead and held on to beat the Tampa Bay Buccaneers 42-28 for their 10th straight home win
Jordan Howard scored two touchdowns and the Chicago Bears' defense had two others in a 41-9 win over the Buffalo Bills.
Danielle Hunter had 3 1/2 of the Vikings' franchise-record 10 sacks to help make it a miserable afternoon for Matthew Stafford and the Lions in a 24-9 victory
Nick Mullens threw for 262 yards and three touchdowns and the 49ers thoroughly dominated the Battle of the Bay, beating the Raiders 34-3.
Terrell Owens will receive his Hall of Fame ring at a ceremony during the San Francisco 49ers' game against the Oakland Raiders.